As part of the BMBF-funded project INOS, TiN nanoparticles were examined in the human cell lines A549 (lung), HaCaT (skin), and CaCo-2 (intestine). These in vitro tests showed a cytotoxic effect of the TiN particles, which turned out to vary depending on the cell line (utilizing concentrations up to 50 µg / ml over 3 hours and 3 days).

Both a skin irritation test on rabbits and an acute systemic toxicity test on mice resulted in no effects caused by TiN ^[1]. The TiN solutions tested here are used for the coating of implants.

Epidemiological data on TiN-nanoparticles are not available.

Currently there are no studies known that deal with the environmental exposure of TiN nanoparticles.