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    Research regarding the impacts of nanoparticles on people and the environment is needed. The German Federal Ministry of Education and Research funds projects to fill knowledge gaps and to initiate measures to identify and minimize risk.

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Welcome to DaNa

Data on new, innovative and safe application related materials

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DaNa4.0 Logo

DaNa4.0 - Data on new, innovative and safe application related materials

 


 

DaNa4.0 is a science communication project dealing with the safety of novel materials. The project deals with questions whether certain materials could be harmful to humans and/or the environment or whether and how humans and the environment could come into contact with these materials. Complex, toxicological questions from current materials research are prepared in a generally understandable way and presented in a way that is understandable for non-scientists (interested consumers, journalists, politicians, NGOs etc.). These topics are communicated via the website www.nanopartikel.info/www.nanoobjects.info, brochures and info flyers in an interdisciplinary approach with scientists from human toxicology, ecotoxicology, biology, physics and chemistry.

 

 


Grant No.: 03XP0282

Duration: 01.03.2020 - 28.02.2023


 

Project Lead

DECHEMA Logo

Dr. Christoph Steinbach, DECHEMA e.V.

 

Web-Coordination

 

 

Project Partners

 


 

NanoINHAL Logo

NanoINHAL - In-vitro test methods for airborne nanomaterials to investigate toxic potential and uptake after inhalation exposure using innovative organ-on-a-chip technology

Publikationen

Publications

 

 

Inhalation is an important route of administration for nanomaterials and other innovative nano- and microscale materials. Therefore, the lung is an important target organ for acute toxic effects, while at the same time its barrier function determines the systemic absorption of materials and their resulting effects on other organs.

 

The aim of the joint NanoINHAL project is to develop an innovative test system for airborne nanomaterials combining the expertise of the partners in the field of in vitro testing.

The Fraunhofer ITEM in cooperation with the Fraunhofer SCAI has developed a cell exposure system (P.R.I.T. EXPO Cube) that enables the exposure of cell cultures and tissue sections to airborne substances and particles. The suitability of the device for nanoparticle testing has been demonstrated in the InhalT90 and NanoCOLT projects.

The Technical University of Berlin and TissUse are developing organ-on-a-chip systems that allow cell and tissue models to be perfused with medium while simultaneously connecting various organ systems. Such multi-organ systems maintain the function of the organs stable over weeks, making them suitable for long-term studies with repeated substance exposure.

By combining both technologies mentioned above, NanoINHALs’ aim is to develop an on-site test system, which is able to carry out long-term studies with daily repeated real exposure. In addition to the direct effects on the human airway models, the system simultaneously generates data for absorption and effects on secondary organs. Ultimately, the test system will be further assessed in a case study to evaluate the hazard potential of nanoparticles in additive manufacturing processes, such as 3D printing.

 


Grant No. : 03XP0226

Duration: 01.06.2019 - 31.05.2022


 

Project Lead

TUB Logo

 

Prof. Dr. Roland Lauster, Department of Medical Biotechnology (medBT), TU Berlin (TUB), Berlin (DE)

 

 

 

Project Partners

Associated Partners

TissUse GmbH Logo

 

TissUse GmbH, Berlin (DE)

 

 

 


 

 

CarboBreak Project Logo

CarboBreak - Prerequisites and mechanisms for the release of alveolar fibrous carbon fibre fragments

Publications

Publications

 

 

 

Innovative fibre materials and fibre composites have been developed steadily further in recent years and enjoy a rising demand in various applications and products. Especially for carbon fibres (CF) the global demand has more than doubled within the last decade.

Scanning electron microscope image of carbon fibres and critical & health-relevant carbon fibre fragments © BAuAScanning electron microscope image of carbon fibres and critical & health-relevant carbon fibre fragments © BAuA

For the fibres themselves and the polymer composites produced out of them, pre-investigations showed a partially strong tendency towards splintering at mechanical stress and mechanical processing. Up to now it is still unresolved how strong the potential is for releasing alveolar fragments within the entire life cycle of the fibres when stressed mechanically.

In the light of the asbestos problem, the development of material-related expertise on the fracture behaviour of carbon fibres varying in types and provenience is urgently needed. The material conditions of the fibres leading to the formation of alveolar fibrous fragments have to be examined.

 

Occupational safety measures in the carbon fibre pilot plant of the STFI © Sächsisches Textilforschungsinstitut e.V. Occupational safety measures in the carbon fibre pilot plant of the STFI © Sächsisches Textilforschungsinstitut e.V. The increasing importance of carbon fibres especially for lightweight and high-performance applications requires a deeper insight in dust and fibre releasing processes due to the high persistence of graphitic raw materials in biological systems. Joint cross-sectoral efforts of different disciplines such as safety research, materials science and product development are needed.

Objective of the CarboBreak project is a deeper understanding of the splintering behaviour of carbon fibres as well as the investigation of the releasing processes of alveolar fragments from carbon fibres and fibre composites manufactured from carbon material at mechanical stress. Main output of the project will be recommendations concerning work procedures and personal safety as well as the definition of ideal respectively optimised process parameters. The results of CarboBreak provide fundamental contributions for the development of application-safe material innovations.

 

 

 


Grant-No.: 03XP0197

Duration: 01.01.2019 - 31.12.2021


 

Project Lead

Sächsisches Textilforschungsinstitut e.V Logo

 

Dr. Anna Große, Sächsisches Textilforschungsinstitut e.V., Chemnitz (DE)

 

 

Project Partners

 

 


 

 

InnoMat.Life Project Logo

Innovative Materials and new production processes: Safety along the Life Cycle and in industrial value chains

Publikationen

Publications

 

 

In the last 20 years nanosafety research has intensely investigated possible adverse effects of nanomaterials and their mitigation. The focus was on nanomaterials composed of single substances with narrow size distribution and mainly spheroidal geometry such as titanium dioxide and zinc oxide with some additional research on carbon nanotubes and graphene.

However, many more material variants can be found on the market already. Often hybrid materials are used, which are composed of two or more chemical substances. Many of the industrially used materials are polydisperse, meaning that they contain particles in a broad size distribution including sizes beyond the nanoscale. Moreover, in many industrial applications material systems are applied, which change their structure during production or application such as in additive manufacturing. Currently, it remains unclear to which extent the findings of nanosafety research can be applied to these more complex material types.

 

The overarching aim of the InnoMat.Life project is the establishment of criteria and similarity concepts that allow for a grouping based on hazard or risk profiles of those innovative and/or more complex material types. InnoMat.Life focuses on three material classes: (1) polydisperse materials for industrial applications such as metals or polymer powders for additive manufacturing or 3D printing, (2) materials with other and potentially critical morphologies such as rods, plates or fibres and (3) hybrid materials such as mixed organic and inorganic structures. The project addresses exposure and hazards for human and the environment and also considers the whole life cycle of these complex materials from synthesis to disposal.

To achieve these goals the project combines expertise from academia, competent authorities and industry. The results will be presented and discussed in national and international panels and committees to ensure a regulatory applicability of the outcomes from the beginning. The knowledge obtained in the project will support the faster development of safe innovative material systems and allow for timely assessment of possible risks.

 

Project Website: www.innomatlife.de

 


Grant No. : 03XP0216

Duration01.04.2019 - 31.03.2022


 

Project Lead

 

 

Project Partners

BASF Logo

 

BASF SE, Ludwigshafen (DE)

 

Zoz GmbH Logo

 

Zoz GmbH, Wenden(DE)

 

FKM Sintertechnik GmbH (FKM) Logo

FKM Sintertechnik GmbH (FKM), Biedenkopf (DE)

 

3Faktur GmbH Logo

 

3Faktur GmbH, Jena (DE)

 

 

 


 

 

 

Logo MetalSafety

MetalSafety - Development of evaluation concepts for fibrous and granular metal compounds - bioavailability, toxicological efficacy profiles and comparative in vitro, ex vivo and in vivo studies

Publications

Publications

 

 

Metals and their compounds are ubiquitously present in our daily life, for example as components of stainless steel, catalysts, and pigments. Furthermore, metal compounds are being used in numerous innovative processes such as inks for 3D printing or as semiconductors in electronic engineering and medical devices. Apart from granular compounds of different particle sizes, the use of metal-based fibrous materials, so-called nanowires, in various products is increasing. However, many metals and their compounds reveal inflammatory and/or even carcinogenic potentials. Hereby, the toxicity often depends on the respective metal species; decisive factors are oxidation state and solubility and – in case of metal particles - their size (nano-/micro-scaled) as well as structure (granular or fibrous).

The aim of the scientific project MetalSafety is to design comparatively easy-to-use in vitro models for the toxicological evaluation and grouping of different metal-based compounds, which differ in their solubility and bioavailability. One main focus within this project lies on metal-based nanowires, since their toxicological potentials are hardly known. The toxicological profiles of these fibrous structures will be compared to the respective nano-scaled granular as well as water-soluble compounds.

For this purpose, an air-liquid interface (ALI) exposure system will be established to apply fibrous as well as granular structures on in vitro cellular models and to directly measure the deposited mass of the respective compound. The toxicological “finger prints” will be assessed using gene expression profiles, complemented by solubility, uptake and genotoxicity studies.

Afterwards, the results will be compared to complex ex vivo as well as in vivo studies and evaluated with regard to their predictability of the toxicological potential, the mode of action and the dose-response relationship. Species differences between human and rat with respect to toxicodynamic interactions will be obtained on the level of cell culture and precision cut lung slices (PCLS). The respective results will finally compared with data from in vivo studies in rats.

Altogether, the identification of relevant modes of actions by different metals and their compounds is an important prerequisite for a scientific-based derivation of workplace and environmental exposure limit values, including new, innovative metal fibres and granular metal compounds.

 

 


Grant-No.: 03XP0211

Duration: 01.03.2019 - 28.02.2022


 

Project Lead

Karlsruhe Institute of Technology Logo

 

Prof. Dr. Andrea Hartwig, Institute for Applied Biosciences (IAB), Karlsruhe Institute of Technology (KIT), Karlsruhe (DE)

 

 

 

Project Partners

Logo BASF

 

BASF SE, Ludwigshafen (DE)

 

 


 

 

 

Subcategories

Publications

On this page you can find publications resulting from the DaNa2.0 that deals with the topic of Data and knowledge on Nanomaterials - Processing of socially relevant scientific facts .

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the DENANA project that deals with the topic of design criteria for sustainable nanomaterials.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the InhalT-90 project that deals with the topic of 90 days inhalation testing with CeO2 in the rat and subsequent analysis of gene expression profiles for the early detection of toxic / carcinogenic effects.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the NanoBioDetect project that deals with the topic of nanoparticles in the tissue: detection, quantification and presentation of biological effect markers.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the NanoCOLT project that deals with the topic of long-term effect of modified carbon black nanoparticles on healthy and damaged lungs.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

 

Publications

On this page you can find publications resulting from the nanoGRAVUR project that deals with the topic of nanostructured materials – grouping for occupational health, consumer and environmental protection and risk mitigation.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the Nanomobil project that deals with the topic of synthetic silver nanoparticles in the system soil-groundwater - mobility, effects on cohabitation and interaction between hydro-, pedo- and biosphere.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the NanoSuppe Project that deals with the topic of Behaviour of engineered nanoparticles in the pathway wastewater - sewage sludge - plant using the examples TiO2, CeO2, MWCNT and quantum dots.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the NanoUMWELT project that deals with the topic of risk analysis of engineered nanomaterials in the environment: identification, quantification and analysis of the human- and ecotoxicological effects.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the ProCycle project that deals with the topic analysis and toxicological evaluation of dusts from recycling and recycling processes of nanocomposites and strategies for risk minimisation.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the ERA-Net SIINN project FENOMENO that deals with the topic of fate and effect of wastewater-born manufactured nanomaterials in aquatic ecosystems.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the ERA-Net SIINN project NanoIndEx  regarding the topic "Assessment of Individual Exposure to manufactured nanomaterials by means of personal monitors and samplers".

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the ERA-Net SIINN project NanOxiMet regarding the topic "Oxidant generating capacity as a metric to allow grouping of nanomaterials and prediction of human health effects". 

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the DaNa that deals with the topic of Acquisition, evaluation and public-oriented presentation of society-relevant data and findings relating to nanomaterials.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the project CarbonBlack that dealt with the topic of prediction of the human-toxicological effect of synthetic carbon black nanoparticles.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the CarboTox that deals with the topic of Development of screening methods to analyse cancerogenous potential of carbon nano tubes.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the Fe-NANOSIT that deals with the topic of Iron-based nanoparticles and nanocomposite structures for removal of contaminants from groundwater and sewage.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NADINE that deals with the topic of Nanomodified diamond electrodes for inline disinfection in different fields of application.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoExpo that deals with the topic of Nanobalance detectors for individual-related measure-ments of nanoparticle exposures.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoFlow that deals with the topic of Mobility of synthetic nanoparticles in water-saturated and variably water- saturated subsoils.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the nanoGEM that deals with the topic of Nanostructured Materials - health, exposure and material properties.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Further project publications as well as SOPs can be accessed at www.nanogem.de

 

Publications

On this page you can find publications resulting from the NanoKiesel that deals with the topic of Nanoscale silica slurry - Technology developments on nanoscale silica slurry use in mineral building materials with the aim of improving material properties.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoKon that deals with the topic of Systematic evaluation of health effects of nanoscale contrast agents.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoMembrane that deals with the topic of Nanoporous ceramic membranes for use in sustainable closed-cycle water- and solvent-saving methods.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoPharm that deals with the topic of New photocatalytically active composite materials for elimination of pharmaceutical residues.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoMed that deals with the topic of Toxicological characterisation of nano- materials for the diagnostic imaging in medicine.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoPurification that deals with the topic of Development of advanced materials and methods for water and sewage treatment by means of functional nanocomposites.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoSan Project that deals with the topic of A nanotechnological clean up method –In situ use of iron oxide nanoparticles foreliminationof harmful substances from abandoned polluted areas.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the Nano-SCR that deals with the topic of Development of nanoscale SCR catalysts for combined NOx and soot reduction in diesel engines.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the Nanosilver particles that deals with the topic of Mechanisms of action and investigation of their possible interaction with tissues, cells and molecules. Definition of their relevant potential for intolerance.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoTrack that deals with the topic of Nanoparticle life cycle studies based on [45Ti]TiO2 and [105Ag] Ag.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NAPASAN that deals with the topic of Nanoparticles for groundwater damage repair.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the project UMSICHT that delat with the topic of Assessment of the environmental hazards of silver nanomaterials: From chemical particles to technical products.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the INOS that deals with the topic of Identification and Assessment of the Effects of Engineered NanOparticleS on Human and Environmental Health.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the NanoCare project on "A German Initiative on the Health Aspects of Synthetic Nanoparticles: Establishing an Information- and Knowledge-Base for Innovative Material Research".

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the Inno.CNT - CarboLifeCycle.

The full text of some publications is copyright protected and can be made available for a certain fee only.

Publications

On this page you can find publications resulting from the project Inno.CNT - CarboAir on the topic of fibre composite materials for the aeronautical industry and windpower plants.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the project Inno.CNT - CarboSafe dealing with the topic "Studies on the safety of carbon nanotubes (CNTs) for consumers and the environment" .

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

 

 

 

Publications

On this page you can find publications resulting from the CaNTser project dealing with the topic "Investigating the toxic potential of carbon nanotubes after long-term inhalation".

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the NanoBEL project that deals with the topic of biological elimination of complex diagnostic nanoparticles.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Publications

On this page you can find publications resulting from the NanoToxClass project that deals with the topic of establishing nanomaterial grouping / classification strategies according to toxicity and biological effects for supporting risk assessment.

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

 

Publications

On this page you can find publications resulting from the ERA-Net SIINN project CERASAFE that deals with the topic of Safe production and use of nanomaterials in the ceramic industry.

 

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

 

Publications

On this page you can find publications resulting from the CarboBreak project  that deals with the topic of "Prerequisites and mechanisms for the release of respirable fibre-like carbon fragments".

The full text of some publications is copyright protected and can be made available for a certain fee only.

 

Current Research

Graphene interlayer © bonninturina / fotolia.com

Information on the sponsorship programmes of the German Federal Ministry of Education and Research on nanotechnologies for humans and the environment.

Read more...

Knowledge Base

nano © eccolo / fotolia.com

A database with important and generally understandable aspects on health and environment of applied nanomaterials as well as facts on the safety of manufactured nanomaterials.

Read more...

Nano Basics

Graphene © arsdigital / fotolia.com

The chapters on release, exposure, uptake and behavior of nanomaterials in the human body and in the environment as well as the risk assessment will give you a first overview.

Read more...

Current Events

Tue Apr 20 @ 8:00AM - 05:00PM
NanoTox2021

Spotlight Research

Nano-safety - topic of the future

In October we would like to present the special issue "Future Nanosafety" published in "Chemical Research in Toxicology".

In 17 articles operation procedures for future test methods, alternatives for animal testing, safe-by-design processes and detection methods of nanoparticles are presented.

 

 

 

Read more...

 

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