The blood-brain barrier as a barrier to aluminum and aluminum oxide particles has been little studied so far. A damaged blood-brain barrier by high pressures or overdosing may be permeable to nanoparticles.


Animal experiments on mice and rats were carried out to investigate the permeability of the blood-brain barrier. Very high doses of Aluminium particles were administered via the carotid artery, into the veins, the abdomen, and the hollow spaces of the brain of the test animals [1]. Since the experimental doses cannot be compared with the realistic doses, the results must be judged with caution. So far, relevant Aluminium nanoparticle doses have not been proven to cause neurotoxicity [2,3].



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