Very high doses of inhaled aluminiumhydroxide (AlOOH or boehmite) cause signs of inflammation in the lungs of test animals.

 

Within the project NanoCare, two different types of boehmite particles (primary particle sizes of 10 and 40 nm) were scrutinized in in vivo studies. The experiments on rats that were made to inhale up to 28 mg/m3 of the particles five days a week over a period of four weeks showed that inflammation of the lungs due to strongly agglomerated particles only occurred in the presence of the highest concentration. Moreover, enlarged macrophages and lymph node modifications were observed increasingly [1,2,3]. Inflammations in the lungs occurred at inhaled particle doses of more than 1 mg per lung.

Similar results were obtained from instillation experiments carried out within the project. Instillation of more than 1,2 mg of boehmite particles per lung in the respiratory tracts of the test animals caused damage to the lungs. In these studies, the NO(A)EL amounts to 0,6 mg [1].

 

Literature arrow down

  1. NanoCare 2009, Final Scientific Report, ISBN 978-3-89746-108-6. (PDF-Document, 19 MB)
  2. Pauluhn, J (2009), Toxicol Sci, 109(1): 152-167.
  3. Pauluhn, J (2009), Toxicology, 259(3): 140-148.

 

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