Studies in rodents demonstrated that cerium dioxide nanoparticles can be taken up by the animals dependent on the exposure route. There they can induce inflammation but also may act as a radical scavenger and protect the body.

 

Within the project NanoCare short-term inhalation studies (6 hours per day, over 5 days) have been carried out with rats to investigate the adverse effects of cerium dioxide nanoparticles. In this study the inhaled particles could be found within the lung as well as in the lung-associated lymph nodes. Neither in the liver, the kidneys, the spleen nor within the brain and the olfactory bulb any particles could be found [1]. Further investigation of the lung lining fluid could demonstrate the appearance of inflammatory markers after the exposure to CeO2 nanoparticles dependent on the dose administered.

After exposure of animals to cerium dioxide via the food or directly into the blood stream, the particles can be found in various organs such as the liver or the heart. The scavenging effect of oxygen radicals leads to a protective effect of CeO2 for nerve cells [2].

 

Literature arrow down

  1. NanoCare 2009, Final Scientific Report, ISBN 978-3-89746-108-6. (PDF-Dokument, 19 MB).
  2. Hirst, S.M. et. al. (2013), Environ Toxicol, 28(2): 107-118. 

 

 

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