First information on the distribution of graphene-related materials in the body is generated in studies with the aim of biomedical applications. A recent literature study of 34 research articles draws the conclusion, that so far most of the graphene-related materials reveal no harmful effects.


Several graphene-related materials, particularly graphene oxide, are potential candidates for biomedical applications. It is planned e.g. that they reach specific target organs or cells via the blood stream as drug-carriers. Therefore it is no surprise that most in vivo studies investigate the intravenous administration of graphene-related materials and their distribution in the body. Bussy and colleagues stated that 64% of graphene-related materials were administered via this route [1]. Additionally this study revealed that most of the materials described as graphene didn't fulfil the criteria.

Overall, an accumulation of the tested graphene-related materials was found in lung, liver and spleen. However, most of these materials showed no harmful effects. Nevertheless, more studies on this topic are urgently required.


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  1. Bussy, C. et al (2015), Nanoscale, 7: 6432-6435



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