After inhalation platinum nanoparticles behave similar to particles of the same size but from other materials or ultrafine dust. Compared to really toxic materials platinum nanoparticles induce a very small biological effect.

 

Studies with rats and mice did not show toxic effects of platinum nanoparticles after inhalation when compared to carbon black particles or ultrafine dust particles [1]. A very small fraction of the inhaled particles could be found in the liver indicating that these very small particles (Ø 18 nm) can penetrate through the lung tissue into the bloodstream and are then transported to the liver.

A fish-embryo assay demonstrated a considerable less uptake of platinum particles compared to gold or silver particles [2]. The platinum particles did not show an effect on the viability of the fish embryo, but when applied in very high doses the hatching rate was reduced. Direct toxic effects could be observed only in very high concentrations.

 

Literature arrow down

  1. Oberdoerster, G et al. (2000), Res Rep Health Eff Inst,(96): 5-74; disc 75-86.
  2. Asharani, PV et al. (2011), Nanotoxicology, 5(1): 43-54.

 

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