NanoBEL Projekt Logo2

NanoBEL – Biological Elimination of Complex Diagnostic Nanoparticles

publikationen

Publications

 

 

Nanotechnology is one of the key technologies of the 21st century that developed from a basic research to a worldwide important discipline in the last years with an enormous importance in life sciences and medicine. Magnetic nanoparticles play an important role in diagnostic imaging for prevention, therapeutic monitoring and therapy.

NanoBEL medizinische Nano-Anwendungen

Whereas the toxicological effects of acute nanoparticle expositions were widely described in the last years, long-term risks depending on the structure of the nanomaterials and the disease state of the patients have not been systematically investigated.

 

NanoBEL is focused on the risk assessment of the long-term effects of magnetic nanoparticle exposition particularly after repeated administrations, as well as the role of degradation and elimination in the life-cycle of the nanoparticles in diseases like cancer and inflammation. Innovative magnetic nanoparticle formulations with a high relevance for future diagnostic applications are taken into consideration. Beside the development and optimization of magnetic nanoparticles,

NanoBEL contributes to the development and validation of new alternatives to animal-based methods (cell cultures, hen's egg models) to be applied in an integrated safety assessment of the long-term administration of nanoparticles. In close collaboration with DaNa2.0, the systematic collection of the data in a data base accomplish the categorization of nanomaterials, the identification of relevant endpoints, and the risk management.

 

NEW Publications September 2017:

nanoBEL Veröffentlichung LABO

 

Fischer, D. & Rabel M. (2017). Crack the Egg - Ein alternatives Konzept zur Testung von Nanomaterialien. LABO online, Ausgabe 09/2017, pp.52-55, ISSN 0344-5208. (PDF, 820 KB)

 


BMBF Grant No. : 03XP0003

Duration : 01.05.2015 - 30.04.2018


 

Project Lead

Chemicell GmbH Logo

Christian Bergemann, Chemicell GmbH, Berlin (DE)

 

 

Project Partners

Chemicell GmbH Logo

Chemicell GmbH, Berlin (DE)

Dyomics GmbH Logo

Dyomics GmbH, Jena (DE)

 

 

 

 


 

 

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